This drug can cause cancers in men, if taken daily

New Delhi : There is a popular saying ‘excess of anything is bad’. This old proverb suits the way we consume medicine in our daily lives. Daily intake of certain type of drug can cause certain cancers among men, a new research claims.

According to the study conducted by health experts in Northwestern University, men who take once-daily aspirin have nearly double the risk of melanoma (a form of skin cancer) compared to men who are not consume aspirin every day. 

Interestingly, the research claims that women, however, do not have such kind of increased risk associated with consumption of aspirin.

"Given the widespread use of aspirin and the potential clinical impact of the link to melanoma, patients, and healthcare providers need to be aware of the possibility of increased risk for men," said senior study author Beatrice Nardone.

"This does not mean men should stop aspirin therapy to lower the risk of heart attack," she stressed.

Almost half of participants age 65 and over reported taking aspirin daily or every other day, according to a 2005 study. In 2015, about half of a nationwide survey of U.S. adults reported regular aspirin use.

The findings appeared surprising because aspirin is reported to reduce the risk of gastric, colon, prostate and breast cancer. And some previous studies have reported a reduced risk in aspirin-exposed men and an increased risk in aspirin-exposed women.

The author attributed this to the inconsistency of the research methods used in studies that look for associations and risks for cancers.

Among the many possibilities, one reason men may be more susceptible could be related to males (human and animal species) expressing a lower amount of defensive enzymes, like superoxide dismutase and catalase, compared to females, Nardone speculated.

"These lower levels of protective enzymes suggest that a higher level of resulting oxidative cellular damage in men might contribute to the possibility of developing melanoma," said Nardone.

To conduct the study, researchers collected medical record data comprising almost 200,000 patients who were aspirin-exposed or aspirin-unexposed (control group), ages 18-89, with no prior history of melanoma and with a follow-up time of at least five years.

For the aspirin-exposed patient population, the study included only patients who had at least one year of once-daily aspirin exposure at a dose of 81 or 325 mg occurring between January 2005 and December 2006 in order to allow for at least five years of follow-up data to detect if melanoma occurred over time.

Out of a total of 195,140 patients, 1,187 were aspirin exposed. Of these 1,187 patients, 26 (both men and women) had a consequent diagnosis for melanoma compared to 1,676 in aspirin-unexposed (men and women) patients.

When the groups were separated into men and women, men exposed to aspirin had almost twice the risk for diagnosis of melanoma compared to men in the same population who were not exposed to aspirin.

The study and finding is published in the Journal of the American Academy of Dermatology.